Download e-book for iPad: Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in by Falk Nimmerjahn

By Falk Nimmerjahn

ISBN-10: 0123948029

ISBN-13: 9780123948021

Autoimmune issues are characterised via the destruction of self-tissues via the immune method. a number of checkpoints are in position to avoid autoreactivity below basic conditions. Co-expression of activating and inhibitory Fc receptors (FcRs) represents one of these checkpoint by way of developing a threshold for immune mobile activation. in lots of human autoimmune ailments, notwithstanding, balanced FcR expression is disturbed. research of murine version platforms presents powerful facts that aberrant FcR expression may end up in out of control immune responses and the initiation of autoimmune ailment. This evaluate summarizes those information and explains how this data should be used to raised comprehend human autoimmune illnesses and to enhance novel healing strategies.

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Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in Autoimmune Disorders by Falk Nimmerjahn

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